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Thiazolidinediones (glitazones)

November 24th, 2015 | by Australian Association
Thiazolidinediones (glitazones)
Diabetes drugs

Chemical name:

  • Rosiglitazone
  • Pioglitazone

Points to remember about thiazolidinediones (glitazones)

  • They help to lower blood glucose levels by increasing the effect of your own insulin, especially on muscle and fat cells, i.e. they improve insulin resistance
  • Their effect is slow, taking days to weeks to begin working and one to two months for their full effect
  • They work well together with some of the other diabetes tablets
  • Taken on their own, they do not cause hypoglycaemia, but this can occur when they are taken with a sulphonylurea.
  • They should not be taken by people who have liver disease.
  • A side effect is weight gain. Fat is moved from areas where it is bad for your health (around the tummy) to other areas such as the top of the thighs, where you still may not want it but it is not as harmful to your health.
  • Another side effect is fluid accumulation and glitazones should generally be avoided by people with heart failure. Discuss this with your doctor whether or not they are right for you.
  • It is recommended that regular checks of liver function are done particularly in the first year of treatment with these tablets. Your doctor will need to discuss this with you when starting your treatment.

Some Brand Names

  • Rosiglitazone
  • Avandia
  • Pioglitazone
  • Actos

Not to be taken by: women who are pregnant or breast-feeding or if liver disease is present.

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