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DPP-4 inhibitors

November 24th, 2015 | by Australian Association
DPP-4 inhibitors
Diabetes drugs

Chemical name:

  • Linagliptin
  • Saxagliptin
  • Sitagliptin
  • Vildagliptin

Points to remember about DPP-4 inhibitors

  • They work by inhibiting the enzyme DPP-4. This enhances the levels of active incretin hormones which act to lower blood glucose levels by increasing insulin secretion and decreasing glucagon secretion (a hormone that has the opposite effect of insulin by increasing blood glucose levels).
  • By themselves, they are unlikely to cause hypoglycaemia because they do not work when blood glucose levels are low.

Not to be taken by:

  • They should not be used if you are under 18 years of age, are pregnant or intend to become pregnant, while breastfeeding or if planning to breastfeed, or for the management of type 1 diabetes or diabetic ketoacidosis. If you have kidney or liver problems, your doctor may prescribe lower doses.

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