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RESET-IT: Early Intermittent Intensive Therapy as an Effective Treatment of Type 2 Diabetes

August 21st, 2015 | by Canadian Association
RESET-IT: Early Intermittent Intensive Therapy as an Effective Treatment of Type 2 Diabetes


RESET-IT: Early Intermittent Intensive Therapy as an Effective Treatment of Type 2 Diabetes

Name of Applicant

Haysook Choi

Institutions Involved

Mt. Sinai Hospital
Investigators: Dr. R. Retnakaran, Dr. B. Zinman

Funding Source

Canadian Institutes of Health Research (CIHR)

Inclusion Criteria

  • Men or women between ages 30 to 80 years with type 2 diabetes for 5 years or less
  • On either no anti-diabetic medications or on metformin only


In type 2 diabetes, there is a progressive loss of function of the beta cells of the pancreas.  These are the cells that make and secrete insulin which is the hormone primarily responsible for controlling blood sugar.  A growing body of evidence has recently shown that short-term treatment with intensive insulin therapy early in the course of type 2 diabetes can temporarily improve beta cell function.  In this study, we aim at first improving and then preserving pancreatic beta cell function with the ultimate aim of achieving a remission of type 2 diabetes.  This will be attempted by a strategy of short-term use of intensive insulin therapy.  This study may demonstrate an important beta cell protective capacity of short-term intensive insulin therapy.

Rationale for posting

For recruitment

Ethical Approval

Mount Sinai Hospital Research Ethics Board Project

Start date

Currently underway

End date

Approximately 7 years

Contact Information

For more information, please call Haysook Choi, Research Nurse.
Telephone: 416-586-8778.
Email: hchoi@mtsinai.on.ca

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