A new medicine prevents type 1 diabetes in mice, a study suggests.
The research, conducted at Stanford University School of Medicine, may be applicable to humans, at least to some extent, potentially leading to better treatments for type 1 diabetes.
Type 1 diabetes develops largely because of a build-up of a substance called hyaluronan in the pancreas during the pre-symptomatic stage. When the researchers used the drug hymecromone, or 4-methylumbelliferone (4-MU), to prevent this substance from accumulating, insulin-producing beta cells in the pancreas were not damaged, and type 1 diabetes was unable to develop.
The researchers examined the levels of many different substances involved in pancreatic tissue. Hyaluronan, they noticed, was particularly prevalent near the pancreatic beta cells in newly-diagnosed type 1 diabetes patients.
However, this did not necessarily mean that hyaluronan caused the development of type 1 diabetes; there may have merely been a correlation. To determine a causal link, the researchers examined a strain of lab mouse with an immune systemdesigned to attack pancreatic beta cells, making type 1 diabetes inevitable. These mice were compared to mice who develop a version of type 1 diabetes more similar to humans’.
Both types of mice developed hyaluronan around the islet cells. There was a large hyaluronan spike at first, which eventually trailed off, suggesting that the build-up only affects peoplenewly-diagnosed with type 1 diabetes.
“We wondered what would happen if we prevented that build-up,” said Paul Bollyky, Assistant Professor of Infectious Diseases at Stanford University School of Medicine, and senior author of the study. “And we knew a drug that does that.”
4-MU is currently used in Europe and Asia to treat spasms related to gallstones. It has an excellent safety record and is inexpensive.
“It’s even approved in Europe for kids,” Bollyky added.
The researchers gave 4-MU to some mice during the window of time when the immune cells are infiltrating the islet cells, but have yet to destroy them. Other mice did not receive 4-MU. The group that received 4-MU treatment did not develop high blood glucose levels, keeping them diabetes-free for a year. The other group, which did not receive 4-MU, did develop type 1 diabetes.
Suppressing hyaluronan was only effective for treating newly-diagnosed type 1 diabetes, however, while the beta cells still retain some function. In people who have had type 1 diabetes for many years, the beta cells are already destroyed; suppressing hyaluronan cannot bring them back.
If the findings translate to humans, a similar treatment could be developed. Ideally this treatment would prevent the development of type 1 altogether, but, if this isn’t possible, the findings could lead to effective new treatments.
The findings were published in the Journal of Clinical Investigation.
Ratings article
You must be logged in to post a comment.
Pingback: Dentist Anchorage AK
Pingback: MrSanchez
Pingback: โกงชักดาบ
Pingback: Tow Truck In Newark NJ
Pingback: circle
Pingback: 바카라사이트
Pingback: เซ็กซี่ บาคาร่า
Pingback: p651#https://internetnews.net.pl/forum/moda-i-uroda-f6/magazyn-t239.html#p651
Pingback: cbd
Pingback: Wyoming cornhole
Pingback: xe88 apk
Pingback: Melanie Bowen
Pingback: mortgage payment calculator
Pingback: vacant land for sale squamish bc
Pingback: cbd oil benefits
Pingback: https://www.e3solutionsnc.com/does-my-child-have-teen-anxiety-5-signs-to-look-out-for/
Pingback: copy Rolex Replicas watches
Pingback: الخليج
Pingback: watch child porn
Pingback: ignou synopsis
Pingback: Replica Store
Pingback: Thea
Pingback: 카지노사이트
Pingback: dentistry
Pingback: 토토사이트
Pingback: pomoshh-psihologa-online
Pingback: psyhelp_on_line
Pingback: coronavirus
Pingback: 토토사이트
Pingback: 안전한 토토사이트
Pingback: how to steal a motorbicycle
Pingback: PSYCHOSOCIAL
Pingback: rasstanovka hellinger
Pingback: new-kissanime.com
Pingback: Buy viagra canada
Pingback: linkvaom88
Pingback: cialis coupon
Pingback: Cherekasi film 2020
Pingback: online cialis
Pingback: film doktor_liza
Pingback: djoker film
Pingback: Viagra overnight
Pingback: viagra
Pingback: generic viagra
Pingback: viagra online
Pingback: buy viagra online
Pingback: gidonline-filmix.ru
Pingback: generic cialis for sale
Pingback: promote your youtube video
Pingback: koronavirus-v-ukraine-doktor-komarovskiy
Pingback: how much does cialis cost at walmart
Pingback: viagra generic
Pingback: over the counter viagra
Pingback: Canadian Online Pharmacies
Pingback: Canadian Pharcharmy Online
Pingback: viagra generic
Pingback: male ed pills
Pingback: viagra for sale
Pingback: best ed pills
Pingback: erection pills online
Pingback: tadalafil 20 mg
Pingback: canada online pharmacy
Pingback: t.me/psyhell
Pingback: Ïñèõîëîã îíëàéí
Pingback: buy viagra online
Pingback: canada pharmacy
Pingback: Buy cialis online
Pingback: bitly.com
Pingback: viagra 100mg
Pingback: viagra price
Pingback: viagra coupon
Pingback: cheap viagra
Pingback: cialis
Pingback: cialis coupon
Pingback: canadian pharmacy cialis
Pingback: cialis 5mg
Pingback: Buy cialis
Pingback: levitra
Pingback: vardenafil 10 mg
Pingback: levitra vardenafil
Pingback: online casino real money usa
Pingback: online casino usa real money
Pingback: rlowcostmd.com
Pingback: viagra generic
Pingback: online casino real money usa
Pingback: free slots
Pingback: bitly
Pingback: online loans
Pingback: movies-tekstmovies-tekst
Pingback: quick cash loans
Pingback: online payday loans
Pingback: Zemlyane 2005 smotret onlajn
Pingback: viagra prescription
Pingback: online casino real money paypal
Pingback: cialis buy
Pingback: online casino for australia
Pingback: Bovada
Pingback: real money online casino
Pingback: online blackjack casino games
Pingback: 20 cialis
Pingback: pharmacy
Pingback: generic cialis
Pingback: cialis 20
Pingback: batmanapollo.ru
Pingback: 323
Pingback: 525
Pingback: dom2-ru
Pingback: Tenet Online
Pingback: casino online games
Pingback: psy psy psy psy
Pingback: viagra prescription
Pingback: generic viagra
Pingback: Viagra 120mg usa
Pingback: krsmi.ru
Pingback: viagra
Pingback: Viagra 100mg uk
Pingback: Viagra 50 mg cost
Pingback: Viagra 50 mg coupon
Pingback: Viagra 100 mg canada
Pingback: Cialis 40 mg generic
Pingback: sildenafil
Pingback: Cialis 80 mg tablet
Pingback: Cialis 60 mg for sale
Pingback: buy Cialis 10mg
Pingback: Cialis 40mg nz
Pingback: Cialis 40 mg cheap
Pingback: Cialis 60 mg pills
Pingback: like-v.ru
Pingback: where to buy Cialis 60mg
Pingback: cost of Cialis 80mg
Pingback: how to buy sildenafil 200mg
Pingback: tadalafil 20mg over the counter
Pingback: generic drugs
Pingback: where to buy levitra 10 mg
Pingback: lasix 100 mg no prescription
Pingback: furosemide 40 mg without prescription
Pingback: cost of lexapro 20 mg
Pingback: canadian pharmacy no prescription
Pingback: abilify 15mg tablet
Pingback: viagra achat en france
Pingback: aldactone 100 mg without a doctor prescription
Pingback: CFOSPUK
Pingback: MAMprEj
Pingback: fgu0ygW
Pingback: allegra 120 mg tablets
Pingback: allopurinol 300mg australia
Pingback: amaryl 4mg prices
Pingback: amoxicillin 250mg cost
Pingback: ampicillin 250 mg nz
Pingback: antabuse 500mg purchase
Pingback: antivert 25mg for sale
Pingback: arava 20mg purchase
Pingback: buy aricept 5 mg
Pingback: where can i buy arimidex 1mg
Pingback: tamoxifen 10mg pharmacy
Pingback: tadalafil
Pingback: cost of ashwagandha 60caps
Pingback: atarax 10mg online pharmacy
Pingback: cheap augmentin 250/125 mg
Pingback: avapro 150mg tablets
Pingback: how to purchase avodart 0,5mg
Pingback: baclofen 10mg nz
Pingback: order bactrim 800/160mg
Pingback: benicar 10 mg nz
Pingback: canadian pharmacy viagra
Pingback: how to buy Biaxin 250mg
Pingback: Premarin 0,3mg price
Pingback: buspar 5mg for sale
Pingback: calcium carbonate 500 mg over the counter
Pingback: buy sildenafil
Pingback: dizain cheloveka
Pingback: human design
Pingback: cialis for sale
Pingback: casodex 50mg tablets
Pingback: catapres 100 mcg united states
Pingback: cheapest ceclor
Pingback: order generic viagra
Pingback: periactin 4mg pills
Pingback: phenergan nz
Pingback: plaquenil for sale
Pingback: where to buy prednisolone
Pingback: where to buy prevacid
Pingback: prilosec 40mg online
Pingback: proair inhaler coupon
Pingback: cleantalkorg2.ru
Pingback: cleantalkorg2.ru/sitemap.xml
Pingback: procardia medication
Pingback: proscar 5mg price
Pingback: protonix 40 mg pharmacy
Pingback: where can i buy provigil
Pingback: pulmicort 100 mcg purchase
Pingback: pyridium coupon
Pingback: cost of reglan
Pingback: join vk
Pingback: vk login
Pingback: remeron 15 mg otc
Pingback: retin-a cream cost
Pingback: where can i buy revatio
Pingback: where to buy risperdal 4mg
Pingback: robaxin generic
Pingback: rogaine united kingdom
Pingback: seroquel 25 mg price
Pingback: singulair canada
Pingback: skelaxin generic
Pingback: spiriva otc
Pingback: thorazine 50 mg no prescription
Pingback: toprol 25 mg medication
Pingback: tricor 200 mg nz
Pingback: valtrex uk
Pingback: vantin 100mg online pharmacy
Pingback: verapamil 40 mg usa
Pingback: voltaren medication
Pingback: wellbutrin 300mg uk
Pingback: zanaflex cheap
Pingback: try here
Pingback: zocor tablets
Pingback: zyloprim pharmacy
Pingback: where to buy zyprexa 10 mg
Pingback: zyvox 600 mg medication
Pingback: tadalafil 10mg generic
Pingback: buy escitalopram
Pingback: aripiprazole 15 mg purchase
Pingback: svaty7sezon
Pingback: svaty 7 sezon
Pingback: svaty 7
Pingback: pioglitazone united kingdom
Pingback: spironolactone pharmacy
Pingback: fexofenadine canada
Pingback: glimepiride without prescription
Pingback: meclizine canada
Pingback: leflunomide 20mg online
Pingback: how to buy atomoxetine 18mg
Pingback: cheapest anastrozole 1mg
Pingback: irbesartan usa
Pingback: dutasteride cheap
Pingback: where can i buy olmesartan
Pingback: buspirone tablet
Pingback: clonidinemg tablets
Pingback: where to buy cefuroxime 500mg
Pingback: celecoxib for sale
Pingback: citalopram 10 mg otc
Pingback: cephalexin medication
Pingback: ciprofloxacin 1000 mg online pharmacy
Pingback: loratadine pharmacy
Pingback: clindamycin 150 mg united states
Pingback: prochlorperazine 5mg tablets
Pingback: carvedilolmg united kingdom
Pingback: warfarin over the counter
Pingback: rosuvastatin united states